Abstract Pancreatic cancer is one of the most lethal solid malignancies. with few treatment options. We have recently shown that expression of protease activated receptor (PAR)-1 in the tumor microenvironment drives the progression and induces the chemoresistance of pancreatic cancer. As thrombin is the prototypical PAR-1 agonist. https://parisnaturalfoodes.shop/product-category/carb-smart-bread/